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KMID : 0545120140240060765
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Journal of Microbiology and Biotechnology
2014 Volume.24 No. 6 p.765 ~ p.770
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Characterization of CTX-M-14- and CTX-M-15-Producing Escherichia coli and Klebsiella pneumoniae Isolates from Urine Specimens in a Tertiary-Care Hospital
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Kim Se-Mi
Sung Ji-Youn
Cho Hye-Hyun
Kwon Kye-Chul
Koo Sun-Hoe
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Abstract
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This study aimed to characterize CTX-M producers of urinary E. coli and K. pneumoniae isolates and to determine the prevalence of plasmid-mediated antimicrobial resistance genes among them. Minimum inhibitory concentrations (MICs) were determined, and PCR and sequencing were performed. Among the 42 (82.3%) E. coli and 24 (77.4%) K. pneumoniae isolates containing blaCTX-M, blaCTX-M-14 and blaCTX-M-15 were detected in 23 and 19 E. coli isolates, respectively, and in 7 and 17 K. pneumoniae isolates, respectively. CTX-M producers of urinary E. coli and K. pneumoniae were resistant to multiple antibiotics and contained other antimicrobial resistance genes. CTX-M-15 producers contained more antimicrobial resistance genes than did CTX-M-14 producers.
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KEYWORD
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CTX-M-14, CTX-M-15, E. coli, K. pneumoniae, extended-spectrum β-lactamase (ESBL)
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